2 b5 ]8 k/ A2 _3 ptvb now,tvbnow,bttvb 【後續詳細結果資料】 6 U, P/ z' k2 b) s! |" Z" b' Stvb now,tvbnow,bttvb 因為資料庫中追蹤5年的婦女人數有限，結果分析包括一小組婦女(n= 22,278)，且僅限於1998至2000年。該組平均追蹤63個月。TVBNOW 含有熱門話題，最新最快電視，軟體，遊戲，電影，動漫及日常生活及興趣交流等資訊。0 d, Q7 |4 c: u" Z6 M) I
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微小型結轉移病患中(n= 2203)，不論校正或未校正臨床-病理特徵、治療與醫院類型，單用SLNB(5個結節以下)與SLNB併用完整 ALND(9個結節以上)之間並無顯著差異。. ^# j$ }* D7 K
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宏觀型結轉移病患中(n= 20,075)，單一變項分析時，單用SLNB以及SLNB併用完整ALND之間的結果沒有顯著差異(腋下淋巴復發為1.0%vs1.2% [P = .40] ，相對存活為 98.5% vs98.2% [P= .72] ，觀察存活為82.1% vs81.8% [P= .55] )。 ) l% P% H$ P3 u/ E TVBNOW 含有熱門話題，最新最快電視，軟體，遊戲，電影，動漫及日常生活及興趣交流等資訊。$ ~! |0 H' Q1 |" f( `
不過，如前所述，校正臨床-病理特徵、治療與醫院類型之後進行分析時，對宏觀型疾病來說，相較於SLNB併用完整 ALND，單用SLNB治療傾向有不佳結果，但是沒有顯著差異。公仔箱論壇3 E- f! ^9 i. ]* ]; N/ X+ i
6 V% o! K9 v& x* ^6 ^公仔箱論壇 美國外科醫師學會住院醫師計畫臨床獎學金、西北大學Feinberg 醫學院外科支持本研究。# o! S$ b% x0 o4 ~0 ^. U5 y
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J Clin Oncol. 印刷前線上登載於2009年4月13日。TVBNOW 含有熱門話題，最新最快電視，軟體，遊戲，電影，動漫及日常生活及興趣交流等資訊。- I: T2 f( E0 R p/ U9 \3 A: F+ m
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When Sentinel Lymph Node Biopsy is Enough in Breast Cancertvb now,tvbnow,bttvb; {/ C* {- m4 i" u2 m5 A) L5 \
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By Nick MulcahyTVBNOW 含有熱門話題，最新最快電視，軟體，遊戲，電影，動漫及日常生活及興趣交流等資訊。8 _7 w) B# \3 R( e; f1 w
Medscape Medical News : y. d; e0 E* Z; p3 @6 I6 fTVBNOW 含有熱門話題，最新最快電視，軟體，遊戲，電影，動漫及日常生活及興趣交流等資訊。5.39.217.76" f, U$ D+ v3 N
May 19, 2009 — It's a common dilemma for clinicians and their patients with breast cancer: whether or not to perform completion axillary dissection after nodal metastases have been identified by sentinel lymph node biopsy (SLNB). . H6 @+ L. y3 L! R- e' M5.39.217.76: i: W \5 j2 o
A new observational study of 22,278 women suggests that the answer is frequently no, especially if the nodal metastases are microscopic. The study was published online April 13 in the Journal of Clinical Oncology.tvb now,tvbnow,bttvb+ b3 J* a2 d7 C2 }& c$ v# U
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A full axillary dissection may not be necessary for most patients. ) E# i# l5 J7 X, ~6 W/ I公仔箱論壇 6 P% A2 g$ G/ h5 E公仔箱論壇"A full axillary dissection may not be necessary for most patients," senior study author David J. Winchester, MD, told Medscape Oncology. Dr. Winchester is chief of the Division of General Surgery and Surgical Oncology at NorthShore University HealthSystem in Evanston, Illinois. . O$ m# F# R: d" e& R $ L D. w( e+ u3 y/ l; A1 atvb now,tvbnow,bttvbHe explained that, in the study, completion axillary lymph node dissection (ALND) did not improve outcomes in either axillary recurrence or survival for patients with microscopic disease. Furthermore, there may only be a small benefit with regard to those outcomes with completion ALND for those with macroscopic disease, he suggested. % r- v l% i1 {2 _3 m5 O5.39.217.76 / K* W3 G" P# u/ H% g7 D, v% Z5.39.217.76In patients with macroscopic nodal metastases, axillary recurrence and survival were comparable between the 2 treatment groups.5.39.217.760 a3 v% W$ j S3 F8 _5 B4 y# U
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However, after the analysis was adjusted for differences between the 2 groups, there was a nonsignificant trend toward better outcomes for completion ALND than for SLNB alone — hazard ratio for axillary recurrence was 0.58 (95% confidence interval [CI], 0.32 - 1.06) and for overall survival was 0.89 (95% CI, 0.76 - 1.04), Dr. Winchester and colleagues report.2 u# ^# [, U" R8 K' M7 b5 S
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Still, the study results should cause clinicians to not automatically use completion ALND, noted Dr. Winchester.5.39.217.76) G' } M7 G) v
: i# }- q7 r& T) O- Vtvb now,tvbnow,bttvbWe have relied upon that operation too much.7 k! y( Q% B4 D9 F
% a. J5 E- O& i" T! s) c公仔箱論壇"We have relied upon that operation too much, and this paper points out that we may not need to do it in terms of a survival difference or a regional recurrence difference. This is an operation associated with significant morbidity," he said in a statement. 5 {, n8 l: c- ~- U7 Stvb now,tvbnow,bttvb 4 p/ K& \' o1 a1 h5 v公仔箱論壇For instance, the risk for edema is 30% to 40% with completion ALND, and 2% to 5% with SLNB, he said. & G6 N0 b7 G, h& l8 A# U 2 \, h. a/ b/ U9 V$ ^+ n5.39.217.76The need for completion ALND has been debated for some time, and led to theAmerican College of Surgeons Oncology Group (ACOSOG) Z0011 trial comparing the 2 approaches, say the study authors. However, the trial was suspended after 5 years, in 2004, due to low patient accrual.# S6 z. j4 e1 R" V9 M- G2 Y# t7 ]
1 P2 L6 s% i) L2 jAn ad hoc analysis of ACOSOG Z0011 showed that 69% of node-positive patients who refused to enroll went on to undergo completion ALND, Dr. Winchester and coauthors comment. They also say if there is ever another prospective clinical trial comparing the 2 approaches, then the current study's results could provide some "equipoise" for random assignment to SNLB alone. : Q8 w! Z3 g8 z% T公仔箱論壇$ y$ Q0 K h* \' j2 J( b
Shift in Practice; K. d, P) j* \; h1 X, x. C- l& Z
4 V' P* { k* M# X' V/ ~( A# rTVBNOW 含有熱門話題，最新最快電視，軟體，遊戲，電影，動漫及日常生活及興趣交流等資訊。Dr. Winchester and colleagues used data obtained from the National Cancer Data Base on women with clinically node-negative breast cancer who underwent SLNB and who had nodal metastases from 1998 to 2005 (n?= 97,314).tvb now,tvbnow,bttvb( a: I( G& s, b6 O
, x( m# o; H6 N9 J0 v+ FIn addition to evaluating outcomes in these women, the investigators of the new study tallied the proportion of patients undergoing SLNB and completion ALND.tvb now,tvbnow,bttvb- ?5 l! Y# A( g! _3 q5 P5 `+ r" e7 I9 N
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The results indicate that there has been a shift in practice patterns concerning the procedures. 7 g% H! W4 C8 S5.39.217.76 # f3 u! \. y, f: Y2 Y( N9 t- Atvb now,tvbnow,bttvb"For microscopic nodal disease from 1998 to 2005, the proportion of patients undergoing [SLNB] alone without a completion nodal dissection increased considerably, from about 25% to 45%, whereas for patients with more substantial nodal metastases (the macroscopic group), the proportion stayed fairly constant over the time course of the study," said study lead author Karl Bilimoria, MD, MS, in a statement. He was an American College of Surgeons Research Fellow at the time the analysis was performed, and is now a surgical resident at the Feinberg School of Medicine of Northwestern University in Evanston, Illinois.tvb now,tvbnow,bttvb0 n" `9 ] {4 X, r1 b s# n7 ~
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Specifically, the proportion of patients who underwent SLNB alone for macroscopic disease declined during the study period, from 24.2% to 16.7%; (P?< .001); however, the proportion of patients who underwent SLNB alone for microscopic metastases increased, from 24.7% to 45.3% (P?< .001). . S t6 {- @& @3 M 7 A. z' _2 W+ A) mTVBNOW 含有熱門話題，最新最快電視，軟體，遊戲，電影，動漫及日常生活及興趣交流等資訊。Dr. Bilimoria speculated that the increase in the use of SNLB alone for microscopic disease arose as physicians "anecdotally found that nodal dissection is not necessary in all patients."% \: N$ `( {9 y, a n# B
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Outcomes Data in Further Detail公仔箱論壇' `# `) |$ L# p6 v8 N# e
2 H) [5 L5 x1 N. g9 i9 xtvb now,tvbnow,bttvbBecause there was a limited number of women with 5-year follow-up in the database, the outcomes analysis comprised a smaller group of women (n?= 22,278) and was limited to the years 1998 to 2000. The group had a median follow-up of 63 months. 1 w3 a/ J" ]( ^ \ q: j( n% Z5.39.217.76 0 `: [2 H4 }5 _5.39.217.76In patients with microscopic nodal metastases (n?= 2203), there was not a significant difference in outcomes between SLNB alone (5 or fewer nodes) and SLNB with completion ALND (9 or more nodes) — either unadjusted or adjusted for differences in clinico-pathologic characteristics, treatment, and hospital type. 4 n# w1 @2 f% m, c# rtvb now,tvbnow,bttvb3 [* Y6 T0 E, n) E, W! e N
In patients with macroscopic nodal metastases (n?= 20,075), on univariate analysis, there was not a significant difference in outcomes between SLNB alone and SLNB with completion ALND (1.0% vs1.2% [P = .40] for axillary recurrence, 98.5% vs98.2% [P?= .72] for relative survival, and 82.1% vs81.8% [P?= .55] for observed survival).tvb now,tvbnow,bttvb% I. o7 }2 Z2 }% ]
TVBNOW 含有熱門話題，最新最快電視，軟體，遊戲，電影，動漫及日常生活及興趣交流等資訊。* c9 ^. ?. J; i+ q+ p
However, as noted above, after the analysis was adjusted for differences in clinico-pathologic characteristics, treatment, and hospital type, there was a nonsignificant trend toward worse outcomes with SLNB alone than with SLNB with completion ALND for macroscopic disease. + T2 X; a1 s* P& h5.39.217.76! [: k/ x$ U5 ?
The study was supported by the American College of Surgeons Clinical Scholars in Residence program and the Department of Surgery, Feinberg School of Medicine, Northwestern University.5.39.217.767 A3 U: o3 @. n/ s. M( p
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J Clin Oncol. Published online before print April, 13 2009.
